Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
β Scribed by Yu, Dihua; Hung, Mien-Chie
- Book ID
- 110064284
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 140 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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## Abstract DNA copy number amplification at the chromosomal region of 17q is frequent in gastric cancer. Recently 17q21 was identified as the critical region for the amplicon formation because this region harbors the __ERBB2__ oncogene and several other targets, such as __TOP2A__ and __DARPP32__.
## Abstract ErbB2 is overexpressed in approximately 30% of breast cancer patients with a correlation to poor prognosis. ErbB2 has been identified as a useful receptor for molecular targeting. A cyclic 20 amino acid phage display random peptide library was constructed using the fUSE5 gene III system