Overexpression of ErbB2 and ErbB3 receptors in Schwann cells of patients with Charcot–Marie–Tooth disease type 1A
✍ Scribed by Roberto Massa; Camilla Palumbo; Tiziana Cavallaro; Maria Beatrice Panico; Roberto Bei; Chiara Terracciano; Nicolò Rizzuto; Giorgio Bernardi; Andrea Modesti
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 321 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0148-639X
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Charcot-Marie-Tooth Disease (CMT) is the most common cause of peripheral neuropathy, with an incidence of 1:2500 persons affected. Previously, we reported the use of fluorescence in situ hybridization (FISH) to detect the common submicroscopic duplication of 17p12 found in more than 98 per cent of i
## Abstract Expression profiling was performed on sciatic nerve of normal mice and of transgenic mice overexpressing the peripheral myelin protein 22 kDa (PMP22). These mice represent a model for the hereditary peripheral neuropathy Charcot‐Marie Tooth type 1A. Comparison of the profiles reveals th
Charcot-Marie-Tooth (CMT) disease comprises a heterogeneous group of peripheral neuropathies characterized by muscle weakness and wasting, and impaired sensation in the extremities. Four genes encoding an aminoacyl-tRNA synthetase (ARS) have been implicated in CMT disease. ARSs are ubiquitously expr