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Overexpression of DM20 messenger RNA in two brothers with pelizaeus-merzbacher disease

✍ Scribed by Paul Carango; Vicky L. Funanage; Rubén E. Quirós; Craig S. Debruyn; Dr Harold G. Marks


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
775 KB
Volume
38
Category
Article
ISSN
0364-5134

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PLP/DM20 Expression and turnover in a tr
✍ Saadia A. Karim; Jennifer A. Barrie; Mailis C. Mcculloch; Paul Montague; Julia M 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 950 KB

## Abstract The most common cause of Pelizaeus‐Merzbacher (PMD) is due to duplication of the __PLP1__ gene but it is unclear how increased gene dosage affects PLP turnover and causes dysmyelination. We have studied the dynamics of PLP/DM20 in a transgenic mouse model of PMD with increased gene dosa