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OVEREXPRESSION OF DIFFERENT MEMBERS OF THE TYPE 1 GROWTH FACTOR RECEPTOR FAMILY AND THEIR ASSOCIATION WITH CELL PROLIFERATION IN PERIAMPULLARY CARCINOMA

✍ Scribed by VAIDYA, PRADEEP; KAWARADA, YOSHIFUMI; HIGASHIGUCHI, TAKASHI; YOSHIDA, TOSHIMICHI; SAKAKURA, TERUYO; YATANI, RYUICHI

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 685 KB
Volume: 178
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199602)178:2<140::aid-path450>3.0.co;2-u

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✦ Synopsis

The expression of epidermal growth factor receptor (EGFR), c-evbB-2, and c-evbB-3 was examined immunohistochemically in 57 cases of periampullary carcinoma. The percentage of Ki-67-positive cells was also examined in the same tissue, to determine the relationship between the expression of the members of the type 1 growth factor receptor family and cell proliferation. In carcinoma of the head of pancreas, the percentage of cases with overexpression of c-evbB-3 was significantly higher than with overexpression of c-erbB-2 and EGFR. In contrast, in lower bile duct carcinoma and carcinoma of the ampulla of Vater, the percentages of cases with overexpression of c-evbB-2 was greater than with overexpression of other growth factor receptors. A higher percentage of cases with overexpression of c-erbB-3 in pancreatic head carcinoma and overexpression of c-erbB-2 in carcinoma of the ampulla of Vater was found in Ki-67 antigen-positive cases. Moreover, the overexpression of c-erb-3 in pancreatic head carcinoma, c-erb-2 in ampulla of Vater Carcinoma, and Ki-67 in both carcinomas was found to be associated with poor patient outcome. These results demonstrate that different members of the type 1 growth factor receptor family are overexpressed in different carcinomas of the periampullary region.

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