Overexpression of DcR1 and survivin in genetically modified cells with pleiotropic drug resistance
β Scribed by Irina A Davidovich; Anait S Levenson; Victor V Levenson (Chernokhvostov)
- Book ID
- 116333119
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 312 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0304-3835
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Cell line R9 generated by continuous exposure of MOLT-4 cells to adriamycin was cross-resistant to a variety of unrelated drugs. The following data indicate that diminished.,apoptotic response was the mechanism of acquired pleiotropic drug resistance: (i) apoptosis was a common mechanism of cell dea
## Abstract Dihydrodiol dehydrogenase (DDH) is a member of the aldoβketo reductases superfamily (AKR1C1βAKR1C4), which plays central roles in the metabolism of steroid hormone, prostaglandin and xenobiotics. We have previously detected overexpression of DDH as an indicator of poor prognosis and che