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Overexpression of Cortactin Increases Invasion Potential in Oral Squamous Cell Carcinoma

โœ Scribed by Shin-ichi Yamada; Souichi Yanamoto; Goro Kawasaki; Akio Mizuno; Takayuki K. Nemoto


Book ID
107636403
Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
361 KB
Volume
16
Category
Article
ISSN
1219-4956

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## Abstract Overexpression of cyclin D1, a G1 cell cycle regulator, is often found in many different tumor types, including oral squamous cell carcinomas (SCC). Recent laboratory experiments have demonstrated that cyclin D1 levels can influence radiosensitivity in various cell lines. This study eva

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Overexpression of cyclin D2 was studied in 10 human squamous cell carcinoma lines, to establish whether this gene plays a role in tumor progression. We found that those cell lines that overexpressed cyclin D2 (CCND2) had the most invasive in vivo behavior. The invasive ability of the cell lines was