Overexpression of copper-zinc superoxide dismutase in trisomy 21
✍ Scribed by R. De La Torre; A. Casado; E. López-Fernández; D. Carrascosa; V. Ramírez; J. Sáez
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 277 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The cytoplasmic copper-zinc superoxide dismutase (Cu, Zn SOD; SOD-1) is an abundant and well-conserved intracellular antioxidant enzyme which has been implicated in a number of oxidative stress mediated phenomena, especially Down Syndrome, in which SOD-1 activity is increased due to triplication of
A comparative study was carried out on the hemolysates of 6 trisomic 21 and 6 normal subjects, by electrophoresis in starch gel, determining by a combined staining method both SOD-A (former IPO-dimer) and PGM activity. The enzymes were found statistically to be in a hyperactive status, the ratio of