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Overexpression of CDK inhibitor p16INK4A by adenovirus vector inhibits cardiac hypertrophy in vitro and in vivo

✍ Scribed by Hiroshi Ito; Toshihiro Nozato; Masazumi Watanabe; Yuichi Ono; Susumu Adachi; Hiroyuki Tanaka; Michiaki Hirce; Makoto Sunamori; Fumiaki Marumo


Book ID
117141593
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
151 KB
Volume
33
Category
Article
ISSN
0022-2828

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## Abstract The cell cycle regulatory pathway responsible for the control of the late‐G1 checkpoint is found recurrently altered in human malignant melanoma, often due to lack of functional p16 or pRb (pRb‐1) proteins. Here we examined the ability of p16‐derived peptides to mimic p16 function in tw