Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer
β Scribed by Ngan, Elly S W; Hashimoto, Yoshihiro; Ma, Zhi-Qing; Tsai, Ming-Jer; Tsai, Sophia Y
- Book ID
- 110067244
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 194 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The androgen receptor (AR), a steroid receptor family member, is a ligandβdependent transcription factor that has an integral role in normal prostate development. Alterations in ARβmediated activity can result in abnormal gene expression, dysregulated cell growth and prostate cancer. Co
The androgen receptor (AR) signaling pathway plays an important role during the development of the normal prostate gland, but also during the progression of prostate cancer on androgen ablation therapy. Mutations in the AR gene emerge to keep active the AR signaling pathway and to support prostate c