Overexpression of Bcl-xLin Human Breast Cancer Cells Enhances Organ-Selective Lymph Node Metastasis

ZD1839 (IRESSA), an EGFR-selective tyros

ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells

✍ Fortunato Ciardiello; Rosa Caputo; Gaetano Borriello; Donatella Del Bufalo; Anna 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 339 KB

## Abstract Constitutive bcl‐2 overexpression increases the tumorigenic and metastatic potential of doxorubicin‐resistant, estrogen‐independent, MCF‐7 ADR human breast cancer cells. We evaluated the sensitivity to taxanes (paclitaxel, docetaxel and IDN 5109) of 2 bcl‐2‐overexpressing MCF‐7 ADR clon