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Overexpression of bcl-2 in lymphocytes of psoriatic skin

✍ Scribed by L Yildiz; S Bariş; N Senturk; B Kandemir

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
110 KB
Volume
17
Category
Article
ISSN
0926-9959

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✦ Synopsis

ABSTRACT

Bcl‐2 overexpression in lymphocytes play an important part in immunological and inflammatory diseases. In the present study, we investigated the bcl‐2 expression in dermal lymphocytes of psoriatic skin biopsy samples. From the archives of the Department of Pathology, Ondokuz Mayis University Medical School (Samsun, Turkey), tissue sections belonging to 28 psoriasis cases and 10 chronic non‐specific inflammatory skin disease cases were immunohistochemically stained by bcl‐2. Positive staining was semiquantitatively graded from 1+ to 4+. Of the 28 psoriasis cases 20 were found to express bcl‐2. Our data suggest that bcl‐2‐mediated inflammation plays a part in the pathogenesis and recurrent character of psoriasis.

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