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Overexpression of Annexin A2 Is Associated with Abnormal Ubiquitination in Breast Cancer

✍ Scribed by Shishan Deng; Baoqian Jing; Tianyong Xing; Lingmi Hou; Zhengwei Yang

Book ID
119252969
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
646 KB
Volume
10
Category
Article
ISSN
1672-0229

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✦ Synopsis

Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells. To elucidate the cause of abnormal expression of annexin A2, Western blotting, immunoproteomics and immunohistochemical staining were performed to analyze differentially ubiquitinated proteins between fresh breast cancer tissue and its adjacent normal breast tissue from five female volunteers. We detected an ubiquitinated protein that was up-regulated in the cancer tissue, which was further identified as annexin A2 by mass spectrometry. These results suggest that abnormal ubiquitination and/or degradation of annexin A2 may lead to presence of annexin A2 at high level, which may further promote metastasis and infiltration of the breast cancer cells.

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