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Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells

✍ Scribed by Qing-Quan Li; Zhong-Qing Chen; Jing-Da Xu; Xi-Xi Cao; Qi Chen; Xiu-Ping Liu; Zu-De Xu


Book ID
108586551
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
370 KB
Volume
101
Category
Article
ISSN
1347-9032

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In this study we show that multidrug-resistant (MDR) human KB-VI cells are highly resistant to the cytotoxicity of okadaic acid and calyculin A, 2 toxins from marine sponges that are potent inhibitors of type-I and type-2A protein phosphatases (PPl and PP2A). Cytotoxicity and colony-forming assays i