Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer
✍ Scribed by Henri Rochefort; Vincent Cavailles; Patrick Augereau; Françoise Capony; Thierry Maudelonde; Isabelle Touitou; Marcel Garcia
- Book ID
- 116007400
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 741 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-4731
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## Abstract In this study we examined the ability of interferon‐γ (IFN‐γ) to regulate mammary epithelial cell growth and gene expression, with particular emphasis on two genes: __Maspin__ (a member of serine protease inhibitor superfamily), and the lysosomal aspartyl endopeptidase __cathepsin D__ (
NVESTIGATIONS on causative factors in the I genesis of mammary carcinoma in animals, especially in mice, have made it evident that several factors are involved in its development. Somc years ago it was found that the so-called milk factor, an agent that is transmitted by the mother's milk, plays an