## Abstract Overexpressed epidermal growth receptor factor receptors (EGFRs) are thought to contribute to the malignant phenotype of human glioblastomas (GBMs), but the mechanism is not well understood. We found that SKMGβ3 cells, a rare GBM cell line that maintains EGFR gene amplification __in vit
Overexpression and activation of epidermal growth factor receptor in hemangioblastomas
β Scribed by Gregory J. Chen; Matthias A. Karajannis; Elizabeth W. Newcomb; David Zagzag
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 350 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0167-594X
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## Abstract ## Background To evaluate epidermal growth factor receptor (EGFR) phenotypic expression and related gene status in malignant pleural mesothelioma (MPM) and to correlate the results with patients' prognosis. ## Method Eightyβthree cases of MPM specimens were submitted to immunohistoch
Activation of cells is frequently followed by tyrosine phosphorylation of proteins. To quantify this process, we developed a ratiometric enzyme-linked immunosorbent assay (ELISA) using epidermal growth factor receptors (EGFR) as a model. Microtiter dishes were coated with anti-EGFR monoclonal antibo