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Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924

✍ Scribed by Jazaeri, A. A.; Shibata, E.; Park, J.; Bryant, J. L.; Conaway, M. R.; Modesitt, S. C.; Smith, P. G.; Milhollen, M. A.; Berger, A. J.; Dutta, A.

Book ID: 121484487
Publisher: American Association for Cancer Research
Year: 2013
Tongue: English
Weight: 828 KB
Volume: 12
Category: Article
ISSN: 1535-7163
DOI: 10.1158/1535-7163.MCT-12-1028

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With great interest we read the article by Helleman et al., 1 investigating whether a gene set identified using microarrays could be used to predict platin resistance in ovarian cancer. The authors studied a training set obtained from 24 tumours that were analysed using cDNA microarrays. This set co