Metabolic limitations of the use of nucl
โ
Lukasz Hajdo; Aleksandra Beata Szulc; Barbara Klajnert; Maria Bryszewska
๐
Article
๐
2010
๐
John Wiley and Sons
๐
English
โ 186 KB
๐ 2 views
## Abstract Purine and pyrimidine nucleoside analogs (NAs) are antimetabolites commonly used in cancer therapy. Administered as prodrugs, NAs permeate the mambrane using specialized transporters. Following phosphorylation, they interfere with multiple cellular pocessess inducing cytotoxicity. Toxic