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Overcoming nucleoside analog chemoresistance of pancreatic cancer: A therapeutic challenge

โœ Scribed by Sau Wai Hung; Hardik R. Mody; Rajgopal Govindarajan


Book ID
116335887
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
468 KB
Volume
320
Category
Article
ISSN
0304-3835

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## Abstract Purine and pyrimidine nucleoside analogs (NAs) are antimetabolites commonly used in cancer therapy. Administered as prodrugs, NAs permeate the mambrane using specialized transporters. Following phosphorylation, they interfere with multiple cellular pocessess inducing cytotoxicity. Toxic