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Overcoming immunological tolerance to melanoma: Targeting CTLA-4

✍ Scribed by F Stephen HODI

Book ID
111318795
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
241 KB
Volume
6
Category
Article
ISSN
1743-7555

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Targeting cytotoxic T-lymphocyte antigen
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✍ Steven J. O'Day; Omid Hamid; Walter J. Urba πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 511 KB

## Abstract Cancer immunotherapy centers on modulating the host's tumor‐directed immune response. One promising approach involves augmentation of cell‐mediated immunity by interrupting T‐cell pathways responsible for immune down‐regulation or tolerance. The discovery of cytotoxic T‐lymphocyte antig