Overall andKRAS-specific results of combined cetuximab treatment and chemotherapy for metastatic colorectal cancer: a meta-analysis

Increased toxicity and lack of efficacy

Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II study

✍ Carlos R. Becerra; Eugene P. Frenkel; Raheela Ashfaq; Richard B. Gaynor 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 207 KB 👁 1 views

## Abstract Preclinical and clinical models have demonstrated that cyclooxygenase‐2 (COX‐2) is overexpressed in primary and metastatic colorectal tumors. In preclinical models, there appears to be additive or synergistic effects when combining 5‐Fluorouracil (5‐FU) with nonsteroidal anti‐inflammato