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Over-expression of TIMP-1 in osteoblasts increases the anabolic response to PTH

✍ Scribed by D. Merciris; C. Schiltz; N. Legoupil; C. Marty-Morieux; M.C. de Vernejoul; V. Geoffroy


Book ID
118426643
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
736 KB
Volume
40
Category
Article
ISSN
8756-3282

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Bone loss induced by Runx2 Over-expressi
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## Abstract The Runx2 gene is essential for osteoblast differentiation and function. In vivo over‐expression of Runx2 in osteoblasts increases bone resorption, and blocks terminal osteoblast differentiation. Several lines of evidence suggest that osteoblastic matrix metalloproteinases (MMPs) could