Bone loss induced by Runx2 Over-expressi
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Corinne Schiltz; Christophe Prouillet; Caroline Marty; Didier Merciris; Corinne
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Article
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2010
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John Wiley and Sons
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English
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## Abstract The Runx2 gene is essential for osteoblast differentiation and function. In vivo overβexpression of Runx2 in osteoblasts increases bone resorption, and blocks terminal osteoblast differentiation. Several lines of evidence suggest that osteoblastic matrix metalloproteinases (MMPs) could