## Abstract Elevated expression of p130^Cas^/BCAR1 (breast cancer anti estrogen resistance 1) in human breast tumors is a marker of poor prognosis and poor overall survival. Specifically, p130^Cas^ signaling has been associated with antiestrogen resistance, for which the mechanism is currently unkn
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Over-expression of the p110? but not p110? isoform of PI 3-kinase inhibits motility in breast cancer cells
โ Scribed by Yip, Shu-Chin ;El-Sibai, Mirvat ;Hill, Karen M. ;Wu, Haiyan ;Fu, Zheng ;Condeelis, John S. ;Backer, Jonathan M.
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 345 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0886-1544
- DOI
- 10.1002/cm.20032
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## Abstract In addition to its mitogenic and survival actions, recent evidence indicates that IGFโI can enhance DNA repair, implying IGF activity may limit the efficacy of many therapeutic strategies that rely on induction of DNA damage. Although the individual pathways by which DNA damage and IGFโ