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Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas

โœ Scribed by B. Ozanne; C. S. Richards; F. Hendler; D. Burns; B. Gusterson


Book ID
104505662
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
429 KB
Volume
149
Category
Article
ISSN
0022-3417

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Selective killing of squamous carcinoma
โœ Soji Ozawa; Masakazu Ueda; Nobutoshi Ando; Osahiko Abe; Shinsei Minoshima; Nobuy ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 663 KB

We have conjugated a murine monoclonal antibody (8447) against the human epidermal growth factor (EGF) receptor to gelonin, a 60s ribosome inactivating protein, via N-succinimi-dyI-3-(2-pyridyldithio)propionate (SPDP) and 2-iminothiolane. The 64G7-gelonin conjugate bound to the cell surface in propo