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Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor

โœ Scribed by Hung, Victor K.L.; Tai, Lydia W.; Qiu, Qiu; Luo, Xin; Wong, K.L.; Chung, Sookja K.; Cheung, C.W.


Book ID
122308574
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
537 KB
Volume
60
Category
Article
ISSN
1044-7431

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon