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Ovarian function following chemotherapy for childhood brain tumours

✍ Scribed by Clayton, P. E. ;Shalet, S. M. ;Price, D. A. ;Jones, P. H. Morris

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
447 KB
Volume
17
Category
Article
ISSN
0098-1532

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✦ Synopsis

Pubertal development, basal gonadotrophin, and oestradiol levels were assessed in 21 girls who had received neuroaxis irradiation for a brain tumour followed by adjuvantchemotherapywithcarmustine(BCNU) orlomustine(CCNU)and procarbazine. Thirteen received chemotherapy before the age of 11 years. Ten remained prepubertal at their last assessment, nine of whom showed biochemical evidence of primary ovarian failure. The remaining three were pubertal or adult, and although basal folliclestimulating hormone (FSH) and luteinising hormone (LH) levels were normal, all had shown abnormalities of gonadotrophin secretion previously. Eight girls received chemotherapy after 11 years of age. Only three girls exhibited an elevated basal FSH level or exaggerated FSH response t o GnRH. Ele--

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