Outcome of plasmapheresis in myasthenia gravis: Delayed therapy is not favorable
✍ Scribed by Aditya Mandawat; Anant Mandawat; Henry J. Kaminski; Zaid A. Shaker; Aws A. Alawi; Amer Alshekhlee
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 93 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0148-639X
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✦ Synopsis
Abstract
Introduction: The purpose of this study was to compare the in‐hospital mortality and complication rates after early and delayed initiation of plasma exchange (PLEX) in patients with myasthenia gravis (MG). Methods: Our cohort was identified from the Nationwide Inpatient Sample database for the years 2000 through 2005. Early treatment was defined as therapy with PLEX administered within the first 2 days from hospital admission. Univariate and multivariate analyses were employed. Results: One thousand fifty‐three patients were treated and included in the analysis. A delay in receiving PLEX was associated with higher mortality (6.56% vs. 1.15%, P < 0.001) and increased complications (29.51% vs. 15.29%, P < 0.001). Adjusted analysis showed increased mortality [odds ratio (OR) 2.812; 95% confidence interval (CI) 1.119–7.069] and complications (OR 1.672; 95% CI 1.118–2.501) with delayed PLEX therapy. Conclusions: Delaying PLEX therapy for MG by more than 2 days after admission may lead to higher mortality and complication rates, and thus prompt therapy is warranted. Muscle Nerve 43: 578–584, 2011