Outcome of fetal urinary tract anomalies associated with multiple malformations and chromosomal abnormalities

✍ Scribed by Eduardo A. Oliveira; Antônio C. V. Cabral; Alamanda K. Pereira; Isabela Nelly Machado; José Silvério Santos Diniz; Ana Maria Arruda Lana; Lucele Karine Oliveira Cunha

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 98 KB
• Volume: 21
• Category: Article
• ISSN: 0197-3851
• DOI: 10.1002/1097-0223(200102)21:2<129::aid-pd5>3.0.co;2-j

✦ Synopsis

The purpose of this study was to identify prognostic factors and describe the outcome of prenatally detected renal anomalies associated with multiple malformations and chromosomal defects. Forty-one fetuses were included in the analysis. Prenatal ultrasound reports, neonatal records and autopsy information were retrospectively reviewed. Prognostic factors associated with fetal echography and clinical and laboratory ®ndings on admission were studied. Data were analyzed by univariate analysis in which variables associated with adverse outcome were identi®ed by the Chi-square test or Fisher exact test. The abnormalities associated with renal anomalies were divided into three groups: chromosomal defects (21%), previously described syndromes and conditions (24%), and new sporadic conditions (55%). Of 41 children admitted, 30 (76%) died during the perinatal period. The presence of oligohydramnios was signi®cantly associated with an adverse outcome (OR=11, p=0.05). Male gender was a protective factor against death during the perinatal period (OR=0.11, p=0.01). In conclusion, prenatally detected renal anomalies associated with multiple malformations and chromosomal defects had a poor prognosis. The presence of oligohydramnios increased the risk of death, and male gender had a protective role against poor outcome.