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Outcome assessment in clinical trials evidence for the sensitivity of a health status measure

✍ Scribed by Robert F. Meenan; Jennifer J. Anderson; Lewis E. Kazis; Marlene J. Egger; Mary Altz-Smith; Cecil O. Samuelson Jr; Robert F. Willkens; Marilyn A. Solsky; Stanley P. Hayes; Kenneth L. Blocka; Arthur Weinstein; Maria Guttadauria; Stanley B. Kaplan; John Klippel

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 828 KB
Volume: 27
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780271204

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✦ Synopsis

Health status measures are conceptually relevant to the assessment of clinical outcome in the rheumatic diseases, but their ability to detect meaningful changes in health has not been clearly demonstrated. This report describes the performance of a self-administered health status questionnaire in a randomized, double-blind, 21week comparison of placebo, oral gold, and injectable gold in rheumatoid arthritis patients. Outcome was assessed by standard clinical measures, including joint count, grip strength, and laboratory tests, and by the Arthritis Impact Measurement Scales, a reliable and valid health status measure that assesses physical dis-From the Multipurpose Arthritis Center,

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