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Outbreak of jaundice and hemorrhagic fever in the Southeast of Brazil in 2001: Detection and molecular characterization of yellow fever virus

✍ Scribed by A.M.B. de Filippis; R.M.R. Nogueira; H.G. Schatzmayr; D.S. Tavares; A.V. Jabor; S.C.M. Diniz; J.C. Oliveira; E. Moreira; M.P. Miagostovich; E.V. Costa; R. Galler

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
235 KB
Volume
68
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Between January and March 2001, an outbreak of jaundice and hemorrhagic fever occurred in the state of Minas Gerais, Southeast region of Brazil, in which a mortality rate of 53% was reported. Seroconversion, virus isolation, histopathological and immunohistochemical findings, and reverse transcription‐polymerase chain reaction (RT‐PCR) identified yellow fever virus (YFV) as the etiological agent responsible for the outbreak. Partial nucleotide sequence analysis from a fragment of the YFV genome spanning parts of nonstructural (NS) 5 gene and 3β€² noncoding region (3β€² UTR) showed that the YFV involved in this outbreak belongs to South American genotype I and differs from the Brazilian virus identified in 1996. J. Med. Virol. 68:620–627, 2002. Β© 2002 Wiley‐Liss, Inc.

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