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Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs

✍ Scribed by Peter D. Cole; Angela K. Smith; Barton A. Kamen


Book ID
105991658
Publisher
Springer
Year
2002
Tongue
English
Weight
108 KB
Volume
50
Category
Article
ISSN
0344-5704

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## Abstract Recently, we identified a nucleoside analog named ARC (4‐amino‐6‐hydrazino‐7‐β‐D‐ribofuranosyl‐7H‐Pyrrolo[2,3‐d]pyrimidine‐5‐carboxamide), which has the properties of a general transcriptional inhibitor. Here, we report the characterization of ARC on a panel of colorectal cancer (CRC) c