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Osteoprotegerin (OPG) Produced by Bone Marrow Stromal Cells Protects Breast Cancer Cells from TRAIL-Induced Apoptosis

✍ Scribed by H.L. Neville-Webbe; N.A. Cross; C.L. Eaton; R. Nyambo; C.A. Evans; R.E. Coleman; I. Holen

Book ID
111575101
Publisher
Springer US
Year
2004
Tongue
English
Weight
127 KB
Volume
86
Category
Article
ISSN
0167-6806

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## Abstract Osteoprotegerin (OPG) is a decoy receptor for receptor activator of NF‐κB ligand (RANKL) and TNF‐related apoptosis‐inducing ligand (TRAIL). While RANKL is essential for osteoclastogenesis and facilitates breast cancer migration into bone, TRAIL promotes breast cancer apoptosis. We analy