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Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1α expression through the PI3-K/Akt pathway

✍ Scribed by Gang Song; Qiu-Feng Cai; Yu-Bin Mao; Yan-Lin Ming; Shi-Deng Bao; Gao-Liang Ouyang


Book ID
108584292
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
292 KB
Volume
99
Category
Article
ISSN
1347-9032

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## Abstract Interleukin‐6 (IL6) is a growth and survival factor in human prostate cancer (PCa) cells with aggressive phenotypes and has been implicated in the progression of hormone refractory PCas. In the present study, we characterized the IL6‐triggered PI3K/Akt and MAPK/Erk signaling. We identif