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Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

✍ Scribed by Hur, Eun Mi; Youssef, Sawsan; Haws, M Edward; Zhang, Susan Y; Sobel, Raymond A; Steinman, Lawrence


Book ID
109923320
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
507 KB
Volume
8
Category
Article
ISSN
1529-2908

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## Abstract ## Objective To test the effects of a novel monoclonal antibody (mAb) against human osteopontin (OPN) in the prevention and treatment of collagen‐induced arthritis (CIA) and to elucidate the underlying mechanisms of these effects. ## Methods DBA/1J mice immunized with type II collage