✦ LIBER ✦

Osteopontin expression and function: Role in bone remodeling

✍ Scribed by David T. Denhardt; Masaki Noda

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 299 KB
Volume: 72
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(1998)72:30/31+<92::aid-jcb13>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

The cytokine and cell attachment protein osteopontin (OPN) is not necessary for the development and survival of mice in a clean animal facility. The primary role of OPN appears to be that of facilitating recovery of the organism after injury or infection, which generally causes an increase in its expression. It also is essential for some forms of bone remodeling. OPN stimulates cellular signaling pathways via various receptors found on most cell types and can encourage cell migration. OPN modulates immune and inflammatory responses and possibly negatively regulates Ras signaling pathways. Its apparent ability to enhance cell survival by inhibiting apoptosis may explain why the metastatic proficiency of tumor cells increases with increased OPN expression.

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