Osteoinductive signals and heterotopic ossification

✍ Scribed by Eileen M Shore

• Book ID: 102301361
• Publisher: American Society for Bone and Mineral Research
• Year: 2011
• Tongue: English
• Weight: 60 KB
• Volume: 26
• Category: Article
• ISSN: 0884-0431
• DOI: 10.1002/jbmr.404

✦ Synopsis

B one formation is normally confined to skeletal formation during embryonic development and during skeletal repair in response to injury. However, alterations in the usual processes that regulate when and where bone formation occurs can cause disease. The pathologic condition in which bone forms outside the normal skeleton within soft tissues of the body is described as heterotopic ossification. In most cases, this extraskeletal bone formation is not a primary pathologic event but occurs secondarily, frequently following severe soft tissue trauma. Heterotopic ossification is a relatively common complication of CNS injury (eg, traumatic brain injuries, spinal cord lesions, tumors, and encephalitis), total hip arthroplasty, deep tissue burns, multiple forms of tissue damage (including war-related injuries that lead to amputations), and end-stage cardiac valve