Osteogenic Differentiation of Human Mesenchymal Stem Cells in Collagen Matrices: Effect of Uniaxial Cyclic Tensile Strain on Bone Morphogenetic Protein (BMP-2) mRNA Expression

Mesenchymal stem cell-seeded collagen ma

Mesenchymal stem cell-seeded collagen matrices for bone repair: Effects of cyclic tensile strain, cell density, and media conditions on matrix contraction in vitro

✍ Ruwan D. Sumanasinghe; Jason A. Osborne; Elizabeth G. Loboa 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB 👁 1 views

## Abstract Type I collagen is the most abundant extracellular matrix protein in bone and contains arginine– glycine–aspartic acid sequences that promote cell adhesion and proliferation. We have previously shown that human mesenchymal stem cells (hMSCs) seeded in three‐dimensional (3D) collagen gel