Osteogenesis Imperfecta Type IV : Analysis for Mutations in α2(I) Chains of Type I Collagen by α2(I)-Specific cDNA Synthesis and Polymerase Chain Reaction
✍ Scribed by RICHARD WENSTRUP; ANNE SHRAGO; CHARLOTTE PHILLIPS; PETER BYERS; DANIEL COHN
- Book ID
- 119864240
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 205 KB
- Volume
- 580
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
To determine if some individuals with deforming varieties of osteogenesis imperfecta (OI) carry point mutations in the COL1A2 gene of type-I collagen, we examined collagens synthesized by cell strains from affected individuals for the presence of cysteine in the triple helical domain of the alpha 2
## Abstract The __oim__ mouse is a model of human Osteogenesis Imperfecta (OI) that has deficient synthesis of proα2(I) chains. Cells isolated from __oim__ mice synthesize α1(I) collagen homotrimers that accumulate in tissues. To explore the feasibility of gene therapy for OI, a murine proα2(I) cDN