Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading
β Scribed by Lidan You; Sara Temiyasathit; Peling Lee; Chi Hyun Kim; Padmaja Tummala; Wei Yao; Wade Kingery; Amanda M. Malone; Ronald Y. Kwon; Christopher R. Jacobs
- Book ID
- 116320331
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 384 KB
- Volume
- 42
- Category
- Article
- ISSN
- 8756-3282
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The purpose of this paper is to calculate the bone ~uid pressure in the lacunarΓcanalicular porosity of the cortical bone matrix induced by functional mechanical loading and compare it with that induced by the blood pressure di}erences[ This problem reduces to the problem of determining the bone ~ui
## Abstract An __in vivo__ animal model of bone adaptation was used to examine a possible role for matrix metalloproteinaseβ1 in the local mediation of bone remodeling: to corrode the coupling of osteocytes to the matrix in an attempt to autoregulate the cell's perception of its mechanical environm