Osteocyte: the unrecognized side of bone tissue
β Scribed by G. Y. Rochefort; S. Pallu; C. L. Benhamou
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 638 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0937-941X
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## Abstract In order for osteocytes to perceive mechanical information and regulate bone remodeling accordingly they must be anchored to their extracellular matrix (ECM). To date the nature of this attachment is not understood. Osteocytes are embedded in mineralized bone matrix, but maintain a peri
Microdamage is naturally contained in bone and has been considered to trigger bone remodeling. Osteocytes, which exist in bone matrix forming 3-D cell-to-cell network, provide cellular basis to detect local mechanical environment neighboring the microdamage, and should be involved in the initiating