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Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation

✍ Scribed by Jane B. Lian; Gary S. Stein; Janet L. Stein; André J. van Wijnen

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
103 KB
Volume
72
Category
Article
ISSN
0730-2312

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✦ Synopsis

The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restricted expression. Over the last decade, characterization of the promoter regulatory elements and complexes of factors that control suppression of the osteocalcin gene in osteoprogenitor cells and transactivation in mature osteoblasts has revealed transcriptional regulatory mechanisms that mediate development of the osteoblast phenotype. In this review, we have focused on emerging concepts related to molecular mechanisms supporting osteoblast growth and differentiation based on the discoveries that the osteocalcin gene is regulated by homeodomain factors, AP-1 related proteins, and the bone restricted Cbfa1/AML3 transcription factor.

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