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Osteoblastic metastases from astrocytomas: A report of two cases

✍ Scribed by Longee, Darryl C. ;Friedman, Henry S. ;Phillips, Peter C. ;Burger, Peter C. ;Oakes, W. Jerry ;Heffez, Dan ;Wharam, Moody ;Strauss, Lewis ;Fuller, Gregory N. ;Schold, S. Clifford

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 771 KB
Volume: 19
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950190419

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✦ Synopsis

The spread of primary central nervous system (CNS) neoplasms beyond the confines of the neuraxis is a relatively uncommon observation. Extraneural metastases involving bone are quite rare, and have been observed almost exclusively in cases of medulloblastoma, high-grade (III-IV) astrocytoma, and glioblastoma multiforme. To date there has been only one case reported of bone metastasis from a "well-differentiated" astrocytoma. We now report two cases of astrocytoma in children with diffuse osteoblastic metastases and a fulminant clinical course. These cases demonstrate that due to the potential morphologic heterogeneity of these neoplasms, an initial biopsy diagnosis of low-grade astrocytoma does not always imply a benign clinical course.

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