Osteoarthrosis induced by intra-articular hydrogen peroxide injection and running load

✍ Scribed by Genkyo Kaiki; Prof. Haruo Tsuji; Takanobu Yonezawa; Hiromichi Sekido; Takashi Takano; Shinichiro Yamashita; Norikazu Hirano; Akimi Sano

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 936 KB
• Volume: 8
• Category: Article
• ISSN: 0736-0266
• DOI: 10.1002/jor.1100080515

✦ Synopsis

Abstract

Osteoarthrosis of the rat knee joint was induced successfully by intra‐articular injection of 2% hydrogen peroxide (H~2~O~2~) and running load. In the group receiving two injections of physiological saline with running load, no histological osteoarthrotic knees were developed up to 8 weeks after the injection. In the group receiving two 2% H~2~O~2~ injections and running load, advanced osteoarthrosis occurred in all knees 8 weeks after the first injection, and the Mankin's score of osteoarthrotic knees appeared to be higher than the group receiving two 2% H~2~O~2~ injections without running load (p < 0.004, Kruskal‐Wallis H test). In the rats receiving a single 2% H~2~O~2~ injection with running load and a vitamin E‐enriched diet, the inhibitory effect of vitamin E on the development of osteoarthrosis was statistically significant compared to the regular diet group (p < 0.05, Wilcoxon rank test).