Osteoarthritis and therapy

✍ Scribed by Ge, Zigang ;Hu, Yang ;Heng, Boon Chin ;Yang, Zheng ;Ouyang, Hongwei ;Lee, Eng Hin ;Cao, Tong

• Book ID: 101648795
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 204 KB
• Volume: 55
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.21994

✦ Synopsis

Embryonic development and cartilage regeneration

Anatomy of cartilage. Articular cartilage possesses a zonal architecture that comprises the superficial, middle, and deep zones, each with distinct cellular phenotype and matrix composition (10) (Figure 1). From the superficial zone to the deep zone, chondrocytes decrease in number and increase in size and metabolic activity (11). Collagen orientation changes in the different layers of articular cartilage, progressing from an isotropic arrangement that runs generally parallel to the articular surface to the frankly anisotropic arrangement of the Benninghoff arcade pattern in which the orientation arises perpendicularly from the basal region and arches over to run parallel to the articular surface (12) (Figure 2). Articular cartilage has no pain Supported by the Biomedical Research Counsel, Singapore