Osmotic pressure studies of some phospholipid sols

✍ Scribed by I.W. Kellaway; L. Saunders

• Book ID: 103039302
• Publisher: Elsevier Science
• Year: 1970
• Tongue: English
• Weight: 327 KB
• Volume: 4
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(70)90028-9

✦ Synopsis

The number average molecular weight for ultrasonicated phosphatidyl choline (PC) in water and lysophosphatidyl choline (LPC) in water agreed with values previously determined by light-scattering measurements, indicating a narrow molecular weight distribution. The second virial (solvent interaction) coefficients, As, were also of the order indicated by light scattering measurements.

In 25 per cent (w/w) n-propanol/water, a solvent system selected from a consideration of the ternary phase diagram for PC/n-alkanol/water, aggregates were found to contain only 3 to 4 monomers, for both PC and LPC. A maximum molecular weight was observed for the mixed phospholipids when they were present in weight proportions of 3 LPC to 2 PC, corresponding to molar proportions of approximately 2:1.