Osmotic fragility of erythrocytes in myopathies
β Scribed by A. D. Korczyn; E. Nadler; G. Falewski de Leon
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 152 KB
- Volume
- 224
- Category
- Article
- ISSN
- 0340-5354
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β¦ Synopsis
Erythrocytes taken from patients with myopathy have previously been reported to have increased osmotic fragility. We have examined the osmotic fragility of erythrocytes from patients with various myopathies and from carriers. The osmotic fragility was the same as in unaffected controls.
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Osmotic fragility was examined in red blood cells from dogs with a heritable muscle disorder that clinically resembles a muscular dystrophy. Several erythrocyte abnormalities have been reported in patients with certain forms of muscular dystrophy and it is thought that these changes reflect genetica
The hypoosmotic lysis curve of freshly collected human erythrocytes is consistent with a single Gaussian error function with a mean of 46.5 + 0.25 mM NaCI and a standard deviation of 5.0 Β± 0.4 mM NaCI. After extended storage of RBCs under standard blood bank conditions the lysis curve conforms to th