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Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop

✍ Scribed by Hirata, H.

Book ID: 121826634
Publisher: American Association for the Advancement of Science
Year: 2002
Tongue: English
Weight: 489 KB
Volume: 298
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.1074560

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HES-1 is a vertebrate homologue of the Drosophila basic helix-loop-helix (bHLH) protein Hairy, a transcriptional repressor that negatively regulates neuronal differentiation. HES-1 expression in neuronal precursors precedes and represses the expression of the neuronal commitment gene MASH-1, a bHLH