Oscillapeptins A to F, serine protease inhibitors from the three strains of Oscillatoria agardhii

✍ Scribed by Yusai Itou; Keishi Ishida; Hee Jae Shin; Masahiro Murakami

• Book ID: 104209427
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 707 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00341-5

✦ Synopsis

Oscillapeptins B (2) to F (6), which were congeners of oscillapeptin A (1), were isolated from the three strains of cultured cyanobacterium Oscillatoria agardhii. These structures were established by spectroscopic analysis including the 2D NMR techniques. The absolute configurations of osciUapeptins were determined by the spectral and chemical methods. Oscillapeptins A (1) to E (5) inhibited chymotrypsin and/or elastase, and oscillapeptin F (6) inhibited trypsin and plasmin.