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Orthogonal solid-phase synthesis ofN-glycopeptides using backbone protection to eliminate aspartimide formation

✍ Scribed by Laszlo Urge; Laszlo Otvos

Publisher: Springer Netherlands
Year: 1995
Tongue: English
Weight: 381 KB
Volume: 1
Category: Article
ISSN: 1573-3149
DOI: 10.1007/bf00117956

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✦ Synopsis

The side reaction of aspartimide formation during the activation of aspartic acid-containing peptides was eliminated by using backbone protection. The methodology was applied in the orthogonal solid-phase synthesis of N-glycopeptides.

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