Near-infrared NIR spectra are often pre-processed in order to remove systematic noise such as base-line variation and multiplicative scatter effects. This is done by differentiating the spectra to first or second derivatives, by multiplicative signal Ž . correction MSC , or by similar mathematical filtering methods. This pre-processing may, however, also remove information Ž . from the spectra regarding Y the measured response variable in multivariate calibration applications . We here show how a variant of PLS can be used to achieve a signal correction that is as close to orthogonal as possible to a given Y-vector or Y-matrix. Thus, one ensures that the signal correction removes as little information as possible regarding Y. In the case when Ž . Ž . the number of X-variables K exceeds the number of observations N , strict orthogonality is obtained. The approach is called Ž . orthogonal signal correction OSC and is here applied to four different data sets of multivariate calibration. The results are compared with those of traditional signal correction as well as with those of no pre-processing, and OSC is shown to give substantial improvements. Prediction sets of new data, not used in the model development, are used for the comparisons.