This book helps clinicians and postgraduate students to better understand the evidence in orthodontics and to use an evidence-based approach in their clinical practice. The book is written in a question-and-answer style, and each question is answered according to the hierarchy of evidence. At the end of each answer, an interpretation of the included systematic reviews, randomized clinical trials, or other studies is summarized and critically reviewed to give a better understanding of the evidence. This book covers a wide range of clinical topics, such as the treatment of Class II and Class III malocclusion, molar distalization, impacted canines, maxillary expansion, and temporary anchorage devices. Valuable material is provided on root resorption, white spot lesions, and orthodontic retention. As the book is written in Q&A style, it would be helpful to find the most relevant question without going through the whole chapter. The book includes the most asked questions about clinical orthodontics in discussions and will be a great help for orthodontist to defend their seen and unseen cases in exam.