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Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats

✍ Scribed by Kabirullah Lutfy; Syed M Hossain; Imran Khaliq; Nigel T Maidment


Book ID
110005886
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
207 KB
Volume
134
Category
Article
ISSN
0007-1188

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The endogenous ligand for the orphan opioid receptor, orphanin FQ/nociceptin (OFQ), has recently been characterized. The OFQ peptide sequence contains paired basic amino acids, suggesting the possibility of posttranslational processing to a peptide containing the first 11 amino acids of the OFQ pept

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## Abstract In the central nervous system, glial cells play an important role in inflammatory and immune responses, and opioid peptides have been identified as essential mediators between the nervous and the immune systems. We report the profound upregulation of the opioid‐related nociceptin/orphan